李云琦，性别：男，1980年出生，籍贯：四川，毕业于中国科学院长春应用化学研究所，获得博士学位，教授/研究员/博士生导师，从事高性能材料基础的多学科交叉研究工作。

主要学习工作经历：

1997.9～2001.7 南京大学化学系，理学学士

2001.9～2007.3 中科院长春应化所高分子化学与物理重点实验室，理学博士

2005.5～2006.5 Rutgers大学食品系，交换学生

2007.5～2009.1 Kansas大学分子生物中心，博士后

2009.2～2010.5 Kansas大学应用生物信息实验室，博士后

2010.6～2012.11 Rutgers大学食品系，博士后

2013.1～至今 中科院长春应化所，研究员，博士生导师

     在化学和高分子物理化学学习研究经历的基础上，对分子生物学、生物信息学、蛋白质和食品科学以及高分子复合物等多个领域具有深入研究，阐述了一系列复杂体系的基本物理问题，开发了软件/服务器促进相关领域的深入研究。在以相互作用、分子构象、微结构、聚集和相行为、宏观性质的多个尺度相互联系为主线，拓展了基础物理理论模型在大分子复杂体系的应用，整合了一套对复杂体系行之有效的理论、模拟与实验相结合的多学科交叉研究方法。迄今，已发布了开源软件/服务器6个，在J. Phys. Chem. B, J. Chem. Phys.，Bioinformatics, BMC Bioinformatics, PLoS One，Proteins，Carbohydr. Polym.和Food Hydrocolloids等SCI核心期刊共发表论文30余篇，它引200余次，获得一项美国授权专利。

 

主要承担项目：

中科院长春应用化学研究所启动基金，自然科学基金

 

论文发表：

(1-31)

 

1.            Xia S, Li Y, Xia Q, Zhang X, & Huang Q  Glycosylation of bovine serum albumin via Maillard reaction prevents epigallocatechin-3-gallate-induced protein aggregation. Food Hydrocolloids 2015, 43(0):228-235.

2.            Li Y, Zhao Q, & Huang Q  Understanding complex coacervation in serum albumin and pectin mixtures using a combination of the Boltzmann equation and Monte Carlo simulation. Carbohydr. Polym. 2014, 101(0):544-553.

3.            Li Y, An L, & Huang Q  Replica Exchange Monte Carlo Simulation of Human Serum Albumin–Catechin Complexes. J. Phys. Chem. B 2014, 118(35):10362-10372.

4.            Duan XZ, Zhang R, Li YQ, Yang YB, Shi TF, An LJ, & Huang QR  Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model. Eur Biophys J Biophy 2014, 43(8-9):377-391.

5.            Duan XZ, Li YQ, Zhang R, Shi TF, An LJ, & Huang QR  Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity. Eur Phys J E 2014, 37(8):71.

6.            Li Y & Huang Q  Influence of Protein Self-Association on Complex Coacervation with Polysaccharide: A Monte Carlo Study. J. Phys. Chem. B 2013, 117(9):2615-2624.

7.            Li J, Li Y, Lee T-C, & Huang Q  Structure and Physical Properties of Zein/Pluronic F127 Composite Films. J. Agric. Food Chem. 2013, 61(6):1309-1318.

8.            Duan X, Zhang R, Li Y, Shi T, An L, & Huang Q  Monte Carlo Study of Polyelectrolyte Adsorption on Mixed Lipid Membrane. J. Phys. Chem. B 2013, 117(4):989-1002.

9.            Duan X, Li Y, Zhang R, Shi T, An L, & Huang Q  Regulation of anionic lipids in binary membrane upon the adsorption of polyelectrolyte: A Monte Carlo simulation. AIP Adv. 2013, 3:062128.

10.         Duan X, Li Y, Shi T, Huang Q, & An L  Mutation induced structural variation in membrane proteins: Small but hard to catch. Chemical Research in Chinese Universities 2013, 29(5):1016-1021.

11.         Li Y, Zhang J, Tai D, Russell Middaugh C, Zhang Y, & Fang J  Prots: A fragment based protein thermo-stability potential. Proteins: Structure, Function, and Bioinformatics 2012, 80(1):81-92.

12.         Li Y, Shi T, An L, & Huang Q  Monte Carlo Simulation on Complex Formation of Proteins and Polysaccharides. J. Phys. Chem. B 2012, 116(10):3045-3053.

13.         Li Y, Li J, Xia Q, Zhang B, Wang Q, & Huang Q  Understanding the Dissolution of α-Zein in Aqueous Ethanol and Acetic Acid Solutions. J. Phys. Chem. B 2012, 116(39):12057-12064.

14.         Li Y & Fang J  PROTS-RF: A Robust Model for Predicting Mutation-Induced Protein Stability Changes. PLoS One 2012, 7(10):e47247.

15.         Li Y, Xia Q, Shi K, & Huang Q  Scaling Behaviors of α-Zein in Acetic Acid Solutions. J. Phys. Chem. B 2011, 115(32):9695-9702.

16.         Li Y, Fang Y, & Fang J  Predicting residue-residue contacts using random forest models. Bioinformatics 2011, 27(24):3379-3384.

17.         Li Y, Middaugh CR, & Fang J  A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants. BMC Bioinformatics 2010, 11(1):62.

18.         Li Y & Fang J  Distance-dependent statistical potentials for discriminating thermophilic and mesophilic proteins. Biochem. Biophys. Res. Commun. 2010, 396(3):736-741.

19.         Li Y & Zhang Y  REMO: A new protocol to refine full atomic protein models from C-alpha traces by optimizing hydrogen-bonding networks. Proteins: Structure, Function, and Bioinformatics 2009, 76(3):665-676.

20.         Li Y, Roy A, & Zhang Y  HAAD: A Quick Algorithm for Accurate Prediction of Hydrogen Atoms in Protein Structures. PLoS One 2009, 4(8):e6701.

21.         Song J, Shi T, Li Y, Chen J, & An L  Rigidity effect on phase behavior of symmetric ABA triblock copolymers: A Monte Carlo simulation. J. Chem. Phys. 2008, 129(5):054906.

22.         Li Y, Lee J, Lal J, An L, & Huang Q  Effects of pH on the Interactions and Conformation of Bovine Serum Albumin: Comparison between Chemical Force Microscopy and Small-Angle Neutron Scattering. J. Phys. Chem. B 2008, 112(12):3797-3806.

23.         Wang X, Li Y, Wang YW, Lal J, & Huang Q  Microstructure of beta-lactoglobulin/pectin coacervates studied by small-angle neutron scattering. J. Phys. Chem. B 2007, 111(3):515-520.

24.         Song J, Li Y, Huang Q, Shi T, & An L  Monte Carlo simulation on symmetric ABA/AB copolymer blends in confined thin films. J. Chem. Phys. 2007, 127(9):094903.

25.         Li Y, Shi T, An L, Lee J, Wang X, & Huang Q  Effects of polar group saturation on physical gelation of amphiphilic polymer solutions. J. Phys. Chem. B 2007, 111(42):12081-12087.

26.         Li Y, Shi T, Sun Z, An L, & Huang Q  Investigation of sol-gel transition in pluronic F127/D2O solutions using a combination of small-angle neutron scattering and Monte Carlo simulation. J. Phys. Chem. B 2006, 110(51):26424-26429.

27.         Li Y, Huang Q, Shi T, & An L  How does solvent molecular size affect the microscopic structure in polymer solutions? J. Chem. Phys. 2006, 125(4):044902.

28.         Li Y, Huang Q, Shi T, & An L  Effects of chain flexibility on polymer conformation in dilute solution studied by lattice Monte Carlo simulation. J. Phys. Chem. B 2006, 110(46):23502-23506.

29.         Liao Y, Su Z, Ye X, Li Y, You J, Shi T, & An L  Kinetics of Surface Phase Separation for PMMA/SAN Thin Films Studied by in Situ Atomic Force Microscopy. Macromolecules 2005, 38(2):211-215.

30.         Li Y, Sun Z, Su Z, Shi T, & An L  The effect of solvent size on physical gelation in triblock copolymer solutions. J. Chem. Phys. 2005, 122(19):194909.

31.         Li Y, Sun Z, Shi T, & An L  Conformation studies on sol-gel transition in triblock copolymer solutions. J. Chem. Phys. 2004, 121(2):1133-1140.